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Selection of most relevant publications during 1991 - 2011

  1. Jakobsson, P.J., Odlander, B., Steinhilber, D., Rosén, A. and Claesson, H.E. (1991) Human B-lymphocytes possess 5-lipoxygenase activity and convert arachidonic acid to leukotriene B4. Biochem. Biophys. Res. Commun. 178, 302-308.

  2. Jakobsson, P.J., Steinhilber, D., Odlander, B., Rådmark, O., Claesson, H.E. and Samuelsson, B. (1992). On the expression and regulation of 5-lipoxygenase in human lymphocytes. Proc. Natl. Acad. Sci. USA 89, 3521-3525.

  3. Claesson, H.-E., Jakobsson, P.-J., Steinhilber, D., Odlander, B. and Samuelsson, B. (1993). Expression of 5-lipoxygenase and biosynthesis of leukotriene B4 in human monomorphonuclear leukocytes. J. Lipid Mediators 6, 15-22.

  4. Steinhilber, D., Hoshiko, S., Grunewald, J., Rådmark, O. and Samuelsson, B. (1993). Serum factors regulate 5-lipoxygenase activity in maturating HL-60 cells. Biochim. Biophys. Acta 1178, 1-8.

  5. Steinhilber, D., Rådmark, O. and Samuelsson, B. (1993). Transforming growth factor beta upregulates 5-lipoxygenase activity during myeloid cell maturation. Proc. Natl. Acad. Sci. USA 90, 5984-5988.

  6. Steinhilber, D., Rådmark, O. and Samuelsson, B. (1993). A heat stable serum factor upregulates 5-lipoxygenase activity in HL-60 cells, modulation by TNFalpha or GM-CSF. Biochem. Biophys. Res. Commun. 193, 1083-1090.

  7. Steinhilber, D. (1994). 5-Lipoxygenase: enzyme expression and regulation of activity. Pharm. Acta Helv. 69, 3-14.

  8. Brungs, M., Rådmark, O., Samuelsson, B. and Steinhilber, D. (1994). On the induction of 5-lipoxygenase expression and activity in HL-60 cells: effects of vitamin D3, retinoic acid, DMSO and TGFß. Biochem. Biophys. Res. Commun. 205, 1572-1580.

  9. Rådmark, O., Zhang, Y.-Y., Hammarberg, T., Lind, B., Brungs, M., Steinhilber, D. and Samuelsson, B. (1995). 5-Lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells. Adv. Prostagland. Thromboxane Leukotriene Res. 23, 1-9.

  10. Steinhilber, D., Brungs, M., Rådmark, O. and Samuelsson, B. (1995). Transforming growth factor-beta and 1,25-dihydroxyvitamin D3 induce 5-lipoxygenase activity during myeloid cell maturation. Adv. Prostagland. Thromboxane Leukotriene Res. 23, 449-451.

  11. Brungs, M., Rådmark, O., Samuelsson, B. and Steinhilber, D. (1995). Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor-beta and 1,25-dihydroxyvitamin D3. Proc. Natl. Acad. Sci. USA 92, 107-111.

  12. Steinhilber, D., Brungs, M., Werz, O., Wiesenberg, I., Danielsson, C., Kahlen, J.-P., Nayeri, S., Schräder, M. and Carlberg, C. (1995). The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B-lymphocytes. J Biol. Chem. 270, 7037-7040.

  13. Werz, O., Brungs, M. and Steinhilber, D. (1996) Purification of transforming growth factor beta1 from human platelets. Pharmazie 51, 893-896.

  14. Werz, O. and Steinhilber, D. (1996) Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells - the presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. Eur J Biochem 242, 90-97.

  15. Werz, O., Schneider, N., Brungs, M., Sailer, E.-R., Safayhi, H., Ammon, H.P.T. and Steinhilber, D. (1997) A test system for leukotriene synthesis inhibitors based on the in-vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6. Naunyn Schmiedebergs Arch Pharmacol 356, 441-445.

  16. Benz, M., Werz, O., Jacob, R. and Steinhilber, D. (1997) pH-dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin. Inflamm Res 46, 366-372.

  17. Härle, D., Rådmark, O., Samuelsson, B. and Steinhilber, D. (1998) Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation. Eur J Biochem, 254, 275-281

  18. Werz, O., Szellas, D., Henseler, M. and Steinhilber, D. (1998) Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity, Mol. Pharmacol., 54, 445-451

  19. Werz, O. and Steinhilber, D. (1998) Regulation of 5-lipoxygenase activity by selenium-dependent peroxidases - effects of transforming growth factor-beta and 1,25-dihydroxyvitamin D3, in Recent Adv. Prostagland. Thromboxane Leukotriene Res. Ed. H. Sinzinger, et al., Plenum Press. 383-386.

  20. Steinhilber, D. (1999) 5-lipoxygenase: a target for antiinflammatory drugs revisited. Curr Med Chem 6, 69-83.

  21. Steinhilber, D. and Carlberg, C. (1999) Melatonin receptor ligands. Exp Opin Ther Patents 9, 281-289.

  22. Härle, D., Rådmark, O., Samuelsson, B. and Steinhilber, D. (1999) Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3. Adv Exp Med Biol 469, 105-111.

  23. Straif, D., Werz, O., Kellner, R., Bahr, U. and Steinhilber, D. (2000) Glutathione peroxidase-1 but not 4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. Biochem J 349, 455-461.

  24. Werz, O., Wiesinger, H., Steinmeyer, A. and Steinhilber, D. (2000) New vitamin D receptor agonists with decreased metabolic stability. Biochem Pharmacol 59, 1597-1601.

  25. Wächtershäuser, A., Steinhilber, D., Loitsch, S.M., Caspary, W.F. and Stein, J. (2000) Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. Biochem Biophys Res Commun 268, 778-783.

  26. Werz, O., Szellas, D. and Steinhilber, D. (2000) Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. Eur J Biochem 267, 1263-1269.

  27. Spanbroek, R., Hildner, M., Steinhilber, D., Fusenig, N., Yoneda, K., Samuelsson, O.R. and Habenicht, A.J. (2000) 5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs. Blood 96, 3857-3865.

  28. Loitsch, S.M., von Mallinckrodt, C., Kippenberger, S., Steinhilber, D., Wagner, T.O. and Bargon, J. (2000) Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells. Biochem Biophys Res Commun 276, 571-578.

  29. Gaschott, T., Wächtershäuser, A., Steinhilber, D. and Stein, J. (2001) 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. Biochem Biophys Res Commun 283, 80-85.

  30. Gaschott, T., Steinhilber, D., Milovic, V. and Stein, J. (2001) Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr 131, 1839-1843

  31. Gaschott, T., Werz, O., Steinmeyer, A., Steinhilber, D. and Stein, J. (2001) Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. Biochem Biophys Res Commun 288, 690-696.

  32. Werz, O., Bürkert, E., Rådmark, O., Samuelsson, B. and Steinhilber, D. (2002) Cell stress-induced formation of leukotrienes in human polymorphonuclear leukocytes is calcium-independent. Blood 99, 1044-1052.

  33. Uhl, J., Klan, N., Rose, M., Entian, K.-D., Werz, O., and Steinhilber, D. (2002) The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem 277, 4374-4379.

  34. Altmann, A., Fischer, L., Schubert-Zsilavecz, M., Steinhilber, D. and Werz, O. (2002) Boswellic acids activate p42MAPK and p38MAPK and stimulate calcium mobilisation. Biochem Biophys Res Commun 290, 185-190.

  35. Bürkert, E., Rådmark, O., Samuelsson, B., Steinhilber, D. and Werz, O. (2002) Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes. J Leukocyte Biol 71, 477-486.

  36. Steinmetz, R.D., Fava, E., Nicotera, P. and Steinhilber, D. (2002) A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods 113, 99-110.

  37. Gaschott, T., Steinmeyer, A., Steinhilber, D. and Stein, J. (2002) ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. Biochem Biophys Res Commun 290, 504-509.

  38. Werz, O., Szellas, D., Steinhilber, D. and Rådmark, O. (2002) Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPKAP kinase 2. J Biol Chem 277, 14793-14800.

  39. Werz, O., Bürkert, E., Fischer, L., Szellas, D., Dishart, D., Samuelsson, B., Rådmark, O. and Steinhilber, D. (2002) Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J 16, 1441-1443.

  40. Bürkert, E., Rådmark, O., Steinhilber, D. and Werz, O. (2002) Monocyte-derived soluble protein confers 5-lipoxygenase activity calcium-dependent. Biochem Biophys Res Commun 295, 985-991.

  41. Albert, D., Zündorf, I., Dingermann, T., Müller, W.E., Steinhilber, D. and Werz, O. (2002) Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase Biochem Pharmacol 64, 1767-1775.

  42. Klan, N. and Steinhilber, D. (2003) Transient transfection of the human myeloid cell line Mono Mac 6 using electroporation. BioTechniques 34, 142-147.

  43. Albert, D., Bürkert, E., Steinhilber, D. and Werz, O. (2003) Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol. Biochim Biophys Acta 1631, 85-93.

  44. Bürkert, E., Szellas, D., Rådmark, O., Steinhilber, D. and Werz, O. (2003) Cell-type-dependent activation of 5-lipoxygenase by arachidonic acid. J Leuk Biol 73, 191-200.

  45. Fischer, L., Szellas, D., Rådmark, O., Steinhilber, D. and Werz, O. (2003) Phosphorylation and stimulus-dependent inhibition of cellular 5-lipoxygenase activity. FASEB J , 17, 949-951.

  46. Klan, N., Seuter, S., Schnur, N., Jung, M. and Steinhilber, D. (2003) Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. Biol Chem , 384, 777-785.

  47. Bürkert, E., Arnold, C., Hammarberg, T., Rådmark, O., Steinhilber, D. and Werz, O. (2003) The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. J Biol Chem 278, 42846-42853.

  48. Altmann, A., Pöckel, D., Fischer, L., Schubert-Zsilavecz, M., Steinhilber, D. and Werz, O. (2004) Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 141, 223-232

  49.  Fischer, L., Steinhilber, D. and Werz, O. (2004) Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610. Br. J. Pharmacol. 142, 861-868.

  50. Steinmetz, R. D., Firla, B. and Steinhilber, D. (2004) Inhibition of the functional expression of N-methyl-D-aspartate receptors in a stably transformed cell line by cyclosporin A. Biochem. Pharmacol. 68, 563-571.

  51. Werz, O. and Steinhilber, D. (2005) Development of 5-lipoxygenase inhibitors-lessons from cellular enzyme regulation. Biochem Pharmacol. 70, 327-333.

  52. Daniel, C., Schlauch, T., Zügel, U., Steinmeyer, A., Radeke, H.H., Steinhilber, D. and Stein, J. (2005) 22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities. Eur. J. Clin. Invest. 35, 343-349.

  53. Feisst, C., Albert, D., Steinhilber, D. and Werz, O. (2005) The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Mol. Pharmacol. 67, 1751-1757.

  54. Hörnig, C., Albert, D., Fischer, L., Hörnig, M., Rådmark, O., Steinhilber, D. and Werz, O. (2005) 1-oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid-binding site within the N-terminal C2-like domain. J. Biol. Chem. 280, 26913-26921.

  55. Werz, O. and Steinhilber, D. (2005) Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds. Expert Opin. Ther. Patents 15, 505-519.

  56. Ott, I., Koch, T., Shorafa, H., Bai, Z., Pöckel, D., Steinhilber, D. and Gust, R. (2005) Synthesis, cytotoxicity, cellular uptake and influence on eicosanoid metabolism of cobalt-alkyne modified fructoses in comparison to auranofin and the cytotoxic COX inhibitor Co-ASS. Org Biomol Chem 3, 2282-2286.

  57. Fischer, L., Poeckel, D., Buerkert, E., Steinhilber, D. and Werz, O. (2005) Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases. Biochim Biophys Acta 1736, 109-119.

  58. Werz, O., Tretiakova, I., Michel, A., Ulke-Lemee, A., Hörnig, M., Franke, L., Schneider, G., Samuelsson, B., Rådmark, O. and Steinhilber, D. (2005) Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Proc Natl Acad Sci U S A 102, 13164-13169.

  59. Dishart, D., Schnur, N., Klan, N., Werz, O., Steinhilber, D., Samuelsson, B. and Rådmark, O. (2005) GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. Biochim Biophys Acta 1738, 37-47.

  60. Franke, L., Byvatov, E., Werz, O., Steinhilber, D., Schneider, P. and Schneider, G. (2005) Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors. J Med Chem 48, 6997-7004.

  61. Aleksandrov, D.A., Zagryagskaya, A.N., Pushkareva, M.A., Bachschmid, M., Peters-Golden, M., Werz, O., Steinhilber, D. and Sud'ina, G.F. (2006) Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells. FEBS J 273, 548-557.

  62. Aschrafi, A., Meindl, N., Firla, B., Brandes, R.P. and Steinhilber, D. (2006) Intracellular localization of RORalpha is isoform and cell line-dependent. Biochim Biophys Acta 1763, 805-814.

  63. Buchstaller, H.P., Siebert, C.D., Steinmetz, R., Frank, I., Berger, M.L., Gottschlich, R., Leibrock, J., Krug, M., Steinhilber, D. and Noe, C.R. (2006) Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem 49, 864-871.

  64. Landwehr, J., George, S., Karg, E.M., Poeckel, D., Steinhilber, D., Troschuetz, R. and Werz, O. (2006) Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase. J Med Chem 49, 4327-32.

  65. Lechtken, A., Zundorf, I., Dingermann, T., Firla, B. and Steinhilber, D. (2006) Overexpression, refolding, and purification of polyhistidine-tagged human retinoic acid related orphan receptor RORalpha4. Protein Expr Purif 49, 114-120.

  66. Rakonjac, M., Fischer, L., Provost, P., Werz, O., Steinhilber, D., Samuelsson, B. and Radmark, O. (2006) Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A 103, 13150-13155.

  67. Reynders, V., Loitsch, S.M., Steinhauer, C., Wagner, T.O., Steinhilber, D. and Bargon, J. (2006) Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes. Respir Res 7, 104.

  68. Seuter, S., Sorg, B.L. and Steinhilber, D. (2006) The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4. Biochem Biophys Res Commun 348, 1403-1410.

  69. Sorg, B.L., Klan, N., Seuter, S., Dishart, D., Rådmark, O., Habenicht, A., Carlberg, C., Werz, O. and Steinhilber, D. (2006) Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim Biophys Acta 1761, 686-697.

  70. Werz, O. and Steinhilber, D. (2006) Therapeutic options for 5-lipoxygenase inhibitors. Pharmacol Ther 112, 701-718.

  71. Seuter, S., Vaisanen, S., Rådmark, O., Carlberg, C. and Steinhilber, D. (2007) Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene. Biochim Biophys Acta 1771, 864-872.

  72. Daniel, C., Schröder, O., Zahn, N., Gaschott, T., Steinhilber, D. and Stein, J.M. (2007) The TGFbeta/Smad 3-signaling pathway is involved in butyrate-mediated vitamin D receptor (VDR)-expression. J Cell Biochem 102, 1420-1431.

  73. Franke, L., Schwarz, O., Müller-Kuhrt, L., Hoernig, C., Fischer, L., George, S., Tanrikulu, Y., Schneider, P., Werz, O., Steinhilber, D. and Schneider, G. (2007) Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem 50, 2640-2646.

  74. Schwab, M., Reynders, V., Loitsch, S., Steinhilber, D., Stein, J. and Schröder, O. (2007) Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling. Mol Immunol 44, 3625-3632.

  75. Rådmark, O., Werz, O., Steinhilber, D. and Samuelsson, B. (2007) 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci 32, 332-341.

  76. Lechtken, A., Hörnig, M., Werz, O., Corvey, N., Zündorf, I., Dingermann, T., Brandes, R. and Steinhilber, D. (2007) Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro. Biochem Biophys Res Commun 358, 890-896.

  77. Fischer, L., Hörnig, M., Pergola, C., Meindl, N., Franke, L., Tanrikulu, Y., Dodt, G., Schneider, G., Steinhilber, D. and Werz, O. (2007) The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products. Br J Pharmacol. 152, 471-480.

  78. Schnur, N., Seuter, S., Katryniok, C., Rådmark, O. and Steinhilber, D. (2007) The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. Biochim Biophys Acta 1771, 1271-1282.

  79. Werz, O., Greiner, C., Koeberle, A., Hoernig, C., George, S., Popescu, L., Syha, I., Schubert-Zsilavecz, M. and Steinhilber, D. (2008) Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem 51, 5449-5453.

  80. Maier, T.J., Tausch, L., Hörnig, M., Coste, O., Schmidt, R., Angioni, C., Metzner, J., Groesch, S., Pergola, C., Steinhilber, D., Werz, O. and Geisslinger, G. (2008) Celecoxib inhibits 5-lipoxygenase. Biochem Pharmacol 76, 862-872.

  81. Hofmann, B., Franke, L., Proschak, E., Tanrikulu, Y., Schneider, P., Steinhilber, D. and Schneider, G. (2008) Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase. ChemMedChem 3, 1535-1538.

  82. Schwab, M., Reynders, V., Loitsch, S., Shastri, Y.M., Steinhilber, D., Schroder, O. and Stein, J. (2008) PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. Carcinogenesis 29, 1407-1414.

  83. Poeckel, D., Greiner, C., Verhoff, M., Rau, O., Tausch, L., Hörnig, C., Steinhilber, D., Schubert-Zsilavecz, M. and Werz, O. (2008) Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol 76, 91-97.

  84. Schwab, M., Reynders, V., Loitsch, S., Steinhilber, D., Schröder, O. and Stein, J. (2008) The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. Immunology 125, 241-251.

  85. Michel, A.A., Steinhilber, D. and Werz, O. (2008) Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase. Protein Expr Purif 59, 110-116.

  86. Albert, D., Pergola, C., Koeberle, A., Dodt, G., Steinhilber, D. and Werz, O. (2008) The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes. J Leukoc Biol 83, 1019-1027.

  87. Rau, O., Zettl, H., Popescu, L., Steinhilber, D. and Schubert-Zsilavecz, M. (2008) The treatment of dyslipidemia--what's left in the pipeline? ChemMedChem 3, 206-221.

  88. Schwab, M., Reynders, V., Steinhilber, D. and Stein, J. (2009) Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level. Cancer Lett 273, 98-106.

  89. Feisst, C., Pergola, C., Rakonjac, M., Rossi, A., Koeberle, A., Dodt, G., Hoffmann, M., Hoernig, C., Fischer, L., Steinhilber, D., Franke, L., Schneider, G., Radmark, O., Sautebin, L. and Werz, O. (2009) Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell Mol Life Sci 66, 2759-2771.

  90. Graf, R., Kock, M., Bock, A., Schubert-Zsilavecz, M., Steinhilber, D., Kaufmann, R., Gassenmeier, T., Beschmann, H., Bernd, A. and Kippenberger, S. (2009) Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes. Exp Dermatol 18, 370-377.

  91. Hähnke, V., Hofmann, B., Grgat, T., Proschak, E., Steinhilber, D. and Schneider, G. (2009) PhAST: pharmacophore alignment search tool. J Comput Chem 30, 761-771.

  92. Koenig, M., Huenecke, S., Salzmann-Manrique, E., Esser, R., Quaritsch, R., Steinhilber, D., Radeke, H.H., Martin, H., Bader, P., Klingebiel, T., Schwabe, D., Schneider, G., Lehrnbecher, T., Orth, A. and Koehl, U. (2009) Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populations. Bone Marrow Transplant, in press.

  93. Lindner, S.C., Köhl, U., Maier, T.J., Steinhilber, D. and Sorg, B.L. (2009) TLR2 ligands augment cPLA2{alpha} activity and lead to enhanced leukotriene release in human monocytes. J Leuk Biol 86, 389-399.

  94. Linke, B., Pierre, S., Coste, O., Angioni, C., Becker, W., Maier, T.J., Steinhilber, D., Wittpoth, C., Geisslinger, G. and Scholich, K. (2009) Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing. J Proteome Res 8, 4851-4859.

  95. Maier, T.J., Schiffmann, S., Wobst, I., Birod, K., Angioni, C., Hoffmann, M., Lopez, J.J., Glaubitz, C., Steinhilber, D., Geisslinger, G. and Grosch, S. (2009) Cellular membranes function as a storage compartment for celecoxib. J Mol Med 87, 981-993.

  96. Renner, S., van Otterlo, W.A., Dominguez Seoane, M., Mocklinghoff, S., Hofmann, B., Wetzel, S., Schuffenhauer, A., Ertl, P., Oprea, T.I., Steinhilber, D., Brunsveld, L., Rauh, D. and Waldmann, H. (2009) Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol 5, 585-592.

  97. sser, J., Rakonjac, M., Hofmann, B., Fischer, L., Provost, P., Schneider, G., Steinhilber, D., Samuelsson, B. and Radmark, O. (2009) Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. Biochem J 425, 265-274.

  98. Zettl, H., Schubert-Zsilavecz, M. and Steinhilber, D. (2010) Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors. ChemMedChem 5, 179-185.

  99. Zagryazhskaya, A.N., Lindner, S.C., Grishina, Z.V., Galkina, S.I., Steinhilber, D. and Sud'ina, G.F. (2010) Nitric oxide mediates distinct effects of various LPS chemotypes on phagocytosis and leukotriene synthesis in human neutrophils. Int J Biochem Cell Biol 42, 921-931.

  100. Stoffers, K.L., Sorg, B.L., Seuter, S., Rau, O., Radmark, O. and Steinhilber, D. (2010) Calcitriol Upregulates Open Chromatin and Elongation Markers at Functional Vitamin D Response Elements in the Distal Part of the 5-Lipoxygenase Gene. J Mol Biol 395, 884-896.

  101. Steinbrink, S.D., Pergola, C., Buhring, U., George, S., Metzner, J., Fischer, A.S., Hafner, A.K., Wisniewska, J.M., Geisslinger, G., Werz, O., Steinhilber, D. and Maier, T.J. (2010) Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cell Mol Life Sci 67, 797-806.

  102. Koenig, M., Huenecke, S., Salzmann-Manrique, E., Esser, R., Quaritsch, R., Steinhilber, D., Radeke, H.H., Martin, H., Bader, P., Klingebiel, T., Schwabe, D., Schneider, G., Lehrnbecher, T., Orth, A. and Koehl, U. (2010) Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populations. Bone Marrow Transplant 45, 613-621.

  103. Kocerha, J., Prucha, M.S., Kroll, K.J., Steinhilber, D. and Denslow, N. (2010) Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways. Endocrinology 151, 341-349.

  104. Katryniok, C., Schnur, N., Gillis, A., von Knethen, A., Sorg, B.L., Looijenga, L., Radmark, O. and Steinhilber, D. (2010) Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity. Biochim Biophys Acta 1801, 49-57.

  105. Kaminski, B.M., Loitsch, S.M., Ochs, M.J., Reuter, K.C., Steinhilber, D., Stein, J. and Ulrich, S. (2010) Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-beta/Smad signaling pathway. Mol Nutr Food Res 54, 1486-96.

  106. Hoffmann, M., Lopez, J.J., Pergola, C., Feisst, C., Pawelczik, S., Jakobsson, P.J., Sorg, B.L., Glaubitz, C., Steinhilber, D. and Werz, O. (2010) Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions. Biochim Biophys Acta 1801, 462-972.

  107. Fischer, A.S., Metzner, J., Steinbrink, S.D., Ulrich, S., Angioni, C., Geisslinger, G., Steinhilber, D. and Maier, T.J. (2010) 5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity. Br J Pharmacol 161, 936-949.

  108. Steri, R., Karas, M., Proschak, E., Steinhilber, D., Schneider, G. and Schubert-Zsilavecz, M. (2010) Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription. Future Med Chem 2, 575-586.

  109. Rödl, C.B., Tanrikulu, Y., Wisniewska, J.M., Proschak, E., Schneider, G., Steinhilber, D. and Hofmann, B. (2011) Potent Inhibitors of 5-Lipoxygenase Identified using Pseudoreceptors. ChemMedChem 6, 1001-1005

  110. Revermann, M., Mieth, A., Popescu, L., Paulke, A., Wurglics, M., Pellowska, M., Fischer, A., Steri, R., Maier, T., Schermuly, R., Geisslinger, G., Schubert-Zsilavecz, M., Brandes, R. and Steinhilber, D. (2011) A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine aortic aneurysm model. Br J Pharmacol 163, 1721-1732

  111. Hofmann B, Barzen S, Rödl CB, Kiehl A, Borig J, Zivković A, Stark H, Schneider G, Steinhilber D. (2011) A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. J Med Chem 54, 1943-1947.

  112. Kaminski, B.M., Weigert, A., Brune, B., Schumacher, M., Wenzel, U., Steinhilber, D., Stein, J. and Ulrich, S. (2011) Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. Cancer Chemother Pharmacol 67, 1167-1178.

  113. Kaminski, B.M., Steinhilber, D., Stein, J.M. and Ulrich, S. (2011) Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies. Curr Pharm Biotechnol. in press

  114. Greiner, C., Hornig, C., Rossi, A., Pergola, C., Zettl, H., Schubert-Zsilavecz, M., Steinhilber, D., Sautebin, L. and Werz, O. (2011) 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52) - a novel type 5-lipoxygenase inhibitor with favorable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 164, 781-793.

  115. Ermisch, M., Firla, B. and Steinhilber, D. (2011) Protein kinase A activates and phosphorylates RORalpha4 in vitro and takes part in RORalpha activation by CaMK-IV. Biochem Biophys Res Commun. 408, 442-446.

  116. Pufahl, L., Katryniok, C., Schnur, N., Sorg, B.L., Metzner, J., Grez, M. and Steinhilber, D. (2011) Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. J Cell Mol Med in press.

  117. Ochs, M.J., Steinhilber, D. and Suess, B. (2011) MicroRNA involved in inflammation: Control of eicosanoid pathway. Front Pharmacol 2, 39.

  118. Kerjaschki, D., et al. (2011) Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest 121, 2000-2012.

  119. Hofmann, B., Rödl, C., Kahnt, A., Maier, T., Michel, A., Hoffmann, M., Rau, O., Awwad, K., Pellowska, M., Wurglics, M., Wacker, M., Zivkovic, A., Fleming, I., Schubert-Zsilavecz, M., Stark, H., Schneider, G. and Steinhilber, D. (2011) Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor. Br J Pharmacol in press.

  120. Häfner, A.K., Cernescu, M., Hofmann, B., Ermisch, M., Hörnig, M., Metzner, J., Schneider, G., Brutschy, B. and Steinhilber, D. (2011) Dimerization of human 5-lipoxygenase. Biol Chem in press

 

geändert am 14. Oktober 2011  E-Mail: Webmastersteinhilber@em.uni-frankfurt.de

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