The Graduate Research Program "Roles of Eicosanoids in Biology and Medicine" aims to develop a joint academic and research venture between the Johann Wolfgang Goethe University in Frankfurt and the Department of Medical Chemistry at the Karolinska Institute in Stockholm. The academic goal of the graduate school is to enable qualified graduate students/PhD students and postdoctoral fellows interested in following a career in molecular medicine, pharmacy and biology to extend their understanding of the physiological and pathophysiological roles of eicosanoids in a multidisciplinary scientific environment with access to a wide spectrum of established methods. Scientific aims of the program are to investigate the molecular mechanisms of action of eicosanoids using complementary approaches (chemical, biochemical, molecular, pharmacological, physiological and clinical) designed by both institutions involved in this program. Eicosanoids are lipid autacoids which play a key role in a number of physiological and pathophysiological events, during inflammatory reactions, neoplastic transformation and proliferation. Pioneering work in the field has been performed by the co-applicants from the Karolinska Institute, who are members of the group directed by Professor Bengt Samuelsson. Prof. Samuelsson was awarded the Nobel Prize for his discovery and elucidation of essential pathways and modes of action of eicosanoids in inflammation and cancer. Collaboration between the institutions in Frankfurt and Stockholm was initiated 11 years ago, and has continued to the present day, taking the form of a frequent interexchange of scientists and a number of cooperative short-term research visits and joint projects. The present research and education program extends the realms and intensity of the collaboration which has existed to-date and is intended to make optimal use of the different but complementary experimental approaches and areas of expertise of the two institutions for the education of graduate students. Whereas the Karolinska Institute will preferentially focus on the molecular biology of eicosanoids and arachidonic acid pathways, the pharmacology of eicosanoids and questions related to their clinical relevance will be investigated in Frankfurt. All of the applicants are confident that the collaboration between the two institutions will set new standards in postgraduate education and will make a highly significant scientific contribution to the rapidly expanding field of eicosanoids, their molecular modes of action, involvement in intracellular signalling pathways and their importance in oncology.


The graduate school is sponsored by DFG and Land Hessen.



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Druckversion: 16. August 2007, 12:39